NEW DELHI: In a shift aimed at making medical treatment more relevant to Indian patients, the Indian Council of Medical Research has called for large, multi-centre clinical trials to generate India-specific evidence for treating lifestyle and chronic diseases, instead of relying largely on data from Western countries.The move targets conditions such as diabetes, heart disease, cancer and other non-communicable diseases that affect millions across the country. Health experts say therapies proven effective in Western populations do not always produce the same results in Indian patients because of differences in genetics, diet, climate, disease patterns and access to care.The need for such an approach is already evident in ongoing research.
Dr Ambuj Rao, cardiologist at AIIMS Delhi, said India-specific clinical research is essential, pointing to a pan-India influenza vaccine trial in heart attack patients currently underway at AIIMS. He noted that evidence for such interventions cannot come from Western countries because India has a distinct flu season and different public health challenges.Under the initiative, networks of at least five hospitals will jointly evaluate treatments, medical procedures, digital tools and lifestyle interventions in real-world Indian settings.
The aim is to identify therapies that are not only clinically effective but also affordable and workable within government hospitals and public health programmes. Officials said the findings will directly inform national treatment guidelines, with each selected study eligible for funding of up to Rs 8 crore over four years.Dr Ravinder Goswami from the endocrinology department at AIIMS Delhi said India’s tropical climate, repeated cycles of stress and poverty, and distinct dietary patterns have led to unique metabolic and hormonal adaptations in Indians, including insulin resistance, higher cortisol levels, central obesity and lower muscle mass.
He said rapid lifestyle changes and the growing consumption of refined foods have worsened the burden of diabetes, hypertension, polycystic disorders and other metabolic diseases, which require culturally acceptable and India-specific treatment strategies.
The ICMR’s call for well-planned studies, he added, offers a crucial opportunity to generate evidence for conditions unique to India, including certain metabolic disorders and cancers such as oral cancer.Beyond improving treatment protocols, the programme is also expected to strengthen India’s research capacity. Participating hospitals will be required to conduct trials independently, maintain standardised digital records and share data transparently, reducing dependence on pharmaceutical-driven global research.Public health experts say the initiative could have a direct impact on patients, as even small changes in treatment protocols, backed by Indian evidence, can improve outcomes and reduce out-of-pocket spending for families living with chronic disease. If successful, the effort could ensure that what doctors prescribe in India is guided by data generated from Indian patients, not assumptions imported from elsewhere.
